Mandatory FDA Disclaimer for dietary supplements. These comments have not been approved by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
"Allicin (diallylthiosulfinate) is a defence molecule from garlic (Allium sativum L.) with a broad range of biological activities. Allicin is produced upon tissue damage from the non-proteinogenic amino acid alliin (S-allylcysteine sulfoxide) in a reaction that is catalyzed by the enzyme alliinase. Current understanding of the allicin biosynthetic pathway will be presented in this review. Being a thiosulfinate, allicin is a reactive sulfur species (RSS) and undergoes a redox-reaction with thiol groups in glutathione and proteins that is thought to be essential for its biological activity. Allicin is physiologically active in microbial, plant and mammalian cells. In a dose-dependent manner allicin can inhibit the proliferation of both bacteria and fungi or kill cells outright, including antibiotic-resistant strains like methicillin-resistant Staphylococcus aureus (MRSA). Furthermore, in mammalian cell lines, including cancer cells, allicin induces cell-death and inhibits cell proliferation. In plants allicin inhibits seed germination and attenuates root-development. The majority of allicin's effects are believed to be mediated via redox-dependent mechanisms. In sub-lethal concentrations, allicin has a variety of health-promoting properties, for example cholesterol- and blood pressure-lowering effects that are advantageous for the cardio-vascular system. Clearly, allicin has wide-ranging and interesting applications in medicine and (green) agriculture, hence the detailed discussion of its enormous potential in this review. Taken together, allicin is a fascinating biologically active compound whose properties are a direct consequence of the molecule's chemistry." Source
Mandatory FDA Disclaimer for dietary supplements.
These comments have not been approved by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Since ancient times, garlic has been used to improve health. Now, science is beginning to unlock the mystery behind this mystical plant. The power of raw garlic derives from an enzyme called Alliinase, which is released when the structural integrity of fresh garlic is altered (e.g., cut or crushed). Alliinase catalyzes the formation of sulfenic acids from cysteine sulfoxides. Once formed, sulfenic acids begin transmuting into thiosulfinate compounds. In the case of alliin, the resultant compound is allicin. Allicin is an incredibly potent antioxidant and induces metabolic stress on invasive pathogens by disrupting their defenses and starving them of metabolic elements and compounds.
Allicin is an extremely volatile molecule and will rapidly deteriorate in a natural environment once created. Stabilized allicin may be the key to unlocking some of the benefits of allicin. Stabilized allicin utilizes manufacturing processes that preserve garlic/allicin in a state that makes allicin available when consumed by an individual. Science is only just beginning to understand what health benefits might be available with stabilized allicin.
Mandatory FDA Disclaimer for dietary supplements.
These comments have not been approved by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
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